| 1. Round | 16/07/2021 | Vélez Sarsfield II | - | Racing Club II | 1:1 |  |
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| 3. Round | 26/07/2021 | Vélez Sarsfield II | - | Defensa y Justicia II | 0:0 | ||||
| 4. Round | 02/08/2021 | Atlético Tucumán II | - | Vélez Sarsfield II | 3:0 | ||||
| 5. Round | 06/08/2021 | Vélez Sarsfield II | - | Colón de Santa Fe II | 0:2 | ||||
| 7. Round | 20/08/2021 | Vélez Sarsfield II | - | Lanús II | 1:0 | ||||
| 8. Round | 25/08/2021 | Huracán II | - | Vélez Sarsfield II | 2:2 | |
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| 11. Round | 10/09/2021 | Gimnasia de La Plata II | - | Vélez Sarsfield II | 2:3 | ||||
| 16. Round | 13/10/2021 | Vélez Sarsfield II | - | Arsenal de Sarandí II | 1:1 | ||||
| 17. Round | 19/10/2021 | Central Córdoba SdE II | - | Vélez Sarsfield II | 2:0 | ||||
| 18. Round | 25/10/2021 | Vélez Sarsfield II | - | Boca Juniors II | 1:2 | ||||
| 19. Round | 29/10/2021 | Banfield II | - | Vélez Sarsfield II | 1:2 | ||||
| 20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | |
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| 22. Round | 25/11/2021 | Vélez Sarsfield II | - | Argentinos Juniors II | 1:1 | ||||
| 24. Round | 06/12/2021 | Vélez Sarsfield II | - | Patronato de Paraná II | 1:0 |
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