| 2. Round | 20/08/2021 | Kayserispor | - | Adana Demirspor | 1:1 |  |
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| 5. Round | 18/09/2021 | Adana Demirspor | - | Çaykur Rizespor | 3:1 | ||||
| 6. Round | 21/09/2021 | Beşiktaş | - | Adana Demirspor | 3:3 | ||||
| 7. Round | 25/09/2021 | Adana Demirspor | - | Gaziantep FK | 4:0 | ||||
| 8. Round | 01/10/2021 | Antalyaspor | - | Adana Demirspor | 1:2 | ||||
| 9. Round | 16/10/2021 | Adana Demirspor | - | Yeni Malatyaspor | 0:2 | ||||
| 10. Round | 24/10/2021 | Sivasspor | - | Adana Demirspor | 1:1 | ||||
| 24. Round | 06/02/2022 | Çaykur Rizespor | - | Adana Demirspor | 1:3 |
Turkey