| 1. Round | 23/08/1980 | Lausanne Sports | - | FC Sion | 0:1 | ||||
| 2. Round | 30/08/1980 | FC Sion | - | BSC Young Boys | 2:1 | ||||
| 3. Round | 06/09/1980 | CS Chênois | - | FC Sion | 0:0 | ||||
| 4. Round | 13/09/1980 | FC Sion | - | FC Zürich | 1:3 | ||||
| 5. Round | 20/09/1980 | FC St. Gallen | - | FC Sion | 2:1 | ||||
| 10. Round | 25/10/1980 | FC Sion | - | Neuchâtel Xamax FC | 1:0 | ||||
| 13. Round | 07/12/1980 | AC Bellinzona | - | FC Sion | 0:0 | ||||
| 14. Round | 01/03/1981 | FC Sion | - | Lausanne Sports | 0:0 | ||||
| 15. Round | 08/03/1981 | BSC Young Boys | - | FC Sion | 0:0 | ||||
| 16. Round | 15/03/1981 | FC Sion | - | CS Chênois | 2:2 |  |
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| 17. Round | 21/03/1981 | FC Zürich | - | FC Sion | 3:1 |  |
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| 18. Round | 04/04/1981 | FC Sion | - | FC St. Gallen | 4:1 | ||||
| 19. Round | 11/04/1981 | FC Chiasso | - | FC Sion | 2:4 | |
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| 20. Round | 24/04/1981 | FC Sion | - | FC Basel 1893 | 1:1 | ||||
| 21. Round | 02/05/1981 | FC Sion | - | Grasshopper Club Zürich | 2:2 | ||||
| 22. Round | 09/05/1981 | Neuchâtel Xamax FC | - | FC Sion | 2:1 | ||||
| 23. Round | 16/05/1981 | FC Sion | - | Servette FC | 0:3 | ||||
| 24. Round | 23/05/1981 | FC Luzern | - | FC Sion | 2:2 | ||||
| 25. Round | 04/06/1981 | FC Nordstern Basel | - | FC Sion | 4:0 | ||||
| 26. Round | 13/06/1981 | FC Sion | - | AC Bellinzona | 3:1 |
Switzerland