| 4. Round | 08/02/2020 | Guaraní | - | Club Olimpia | 0:3 dec. |  |
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| 5. Round | 16/02/2020 | Club Nacional | - | Guaraní | 1:2 | ||||
| 7. Round | 01/03/2020 | Sportivo Luqueño | - | Guaraní | 0:3 | ||||
| 8. Round | 07/03/2020 | Guaraní | - | Sol de América | 1:1 | ||||
| 9. Round | 23/07/2020 | Guaireña FC | - | Guaraní | 1:1 | ||||
| 10. Round | 27/07/2020 | Guaraní | - | General Díaz | 0:0 | ||||
| 6. Round | 05/08/2020 | Guaraní | - | River Plate | 3:0 | ||||
| 12. Round | 09/08/2020 | San Lorenzo | - | Guaraní | 1:1 | ||||
| 13. Round | 13/08/2020 | Cerro Porteño | - | Guaraní | 1:0 | ||||
| 17. Round | 29/08/2020 | River Plate | - | Guaraní | 1:0 | ||||
| 20. Round | 20/09/2020 | Guaraní | - | Guaireña FC | 0:0 | |
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| 21. Round | 28/09/2020 | General Díaz | - | Guaraní | 0:1 | ||||
| 22. Round | 04/10/2020 | Guaraní | - | Libertad | 1:1 |
Argentina