| 1. Round | 16/07/2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Round | 27/07/2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Round | 24/08/2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 10. Round | 03/09/2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 13. Round | 24/09/2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 17. Round | 18/10/2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 |
Argentina