| 1. Round | 10/02/2022 | Arsenal de Sarandí II | - | Rosario Central II | 2:1 | ||||
| 2. Round | 15/02/2022 | Rosario Central II | - | Vélez Sarsfield II | 1:1 | ||||
| 4. Round | 26/02/2022 | Rosario Central II | - | Godoy Cruz II | 5:1 | ||||
| 5. Round | 04/03/2022 | Central Córdoba SdE II | - | Rosario Central II | 0:3 | ||||
| 6. Round | 11/03/2022 | Rosario Central II | - | Barracas Central II | 1:2 | ||||
| 7. Round | 18/03/2022 | Rosario Central II | - | Newell's Old Boys II | 2:1 | ||||
| 8. Round | 01/04/2022 | Tigre II | - | Rosario Central II | 1:3 | ||||
| 14. Round | 05/05/2022 | Rosario Central II | - | Estudiantes II | 0:1 |  |
Argentina