| 5. Round | 06/08/2021 | Sarmiento de Junín II | - | Rosario Central II | 2:2 | ||||
| 6. Round | 13/08/2021 | Rosario Central II | - | Independiente II | 3:1 | ||||
| 13. Round | 24/09/2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 |  |
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| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 |
Argentina