| 1. Round | 25/07/2021 | Pumas UNAM [U18] | - | Atlas Guadalajara [U18] | 1:2 | ||||
| 3. Round | 08/08/2021 | Pumas UNAM [U18] | - | Atlético San Luis [U18] | 1:1 | ||||
| 4. Round | 14/08/2021 | Pumas UNAM [U18] | - | Gallos Blancos [U18] | 0:0 | ||||
| 5. Round | 17/08/2021 | Club Necaxa [U18] | - | Pumas UNAM [U18] | 4:2 | ||||
| 6. Round | 22/08/2021 | Pumas UNAM [U18] | - | Puebla FC [U18] | 3:3 |  |
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| 7. Round | 29/08/2021 | Deportivo Toluca [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 8. Round | 12/09/2021 | Pumas UNAM [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 10. Round | 25/09/2021 | UANL Tigres [U18] | - | Pumas UNAM [U18] | 6:0 | ||||
| 16. Round | 30/10/2021 | CF Pachuca [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 11. Round | 04/11/2021 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 2:2 |
Mexico