| 6. Round | 02/07/2022 | River Plate II | - | Huracán II | 1:0 | ||||
| 7. Round | 09/07/2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 8. Round | 16/07/2022 | River Plate II | - | Vélez Sarsfield II | 0:2 | ||||
| 9. Round | 20/07/2022 | Gimnasia de La Plata II | - | River Plate II | 1:3 |  |
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| 10. Round | 25/07/2022 | River Plate II | - | Aldosivi II | 2:0 | ||||
| 11. Round | 30/07/2022 | Sarmiento de Junín II | - | River Plate II | 0:1 | ||||
| 18. Round | 10/09/2022 | River Plate II | - | Boca Juniors II | 1:2 | ||||
| 19. Round | 15/09/2022 | Banfield II | - | River Plate II | 0:1 | ||||
| 20. Round | 19/09/2022 | River Plate II | - | San Lorenzo II | 1:0 | ||||
| 21. Round | 24/09/2022 | Talleres de Córdoba II | - | River Plate II | 5:0 | ||||
| 22. Round | 29/09/2022 | River Plate II | - | Argentinos Juniors II | 1:0 | |
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| 23. Round | 04/10/2022 | Estudiantes II | - | River Plate II | 2:0 | ||||
| 24. Round | 08/10/2022 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 25. Round | 12/10/2022 | Platense II | - | River Plate II | 0:1 | ||||
| 26. Round | 16/10/2022 | Rosario Central II | - | River Plate II | 3:3 | ||||
| 27. Round | 20/10/2022 | River Plate II | - | Racing Club II | 1:2 |
Colombia