| 6. Round | 02/07/2022 | Vélez Sarsfield | - | Atlético Tucumán | 0:1 | ||||
| 7. Round | 10/07/2022 | Atlético Tucumán | - | Gimnasia de La Plata | 2:0 |  |
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| 10. Round | 24/07/2022 | Independiente | - | Atlético Tucumán | 0:1 | ||||
| 11. Round | 31/07/2022 | Atlético Tucumán | - | Newell's Old Boys | 2:0 | ||||
| 13. Round | 12/08/2022 | Atlético Tucumán | - | Central Córdoba SdE | 1:0 | ||||
| 14. Round | 17/08/2022 | Tigre | - | Atlético Tucumán | 0:0 | ||||
| 15. Round | 24/08/2022 | Atlético Tucumán | - | Barracas Central | 4:0 | ||||
| 18. Round | 10/09/2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 20. Round | 20/09/2022 | Argentinos Juniors | - | Atlético Tucumán | 1:2 | ||||
| 21. Round | 26/09/2022 | Atlético Tucumán | - | Estudiantes | 3:1 | ||||
| 22. Round | 02/10/2022 | Patronato de Paraná | - | Atlético Tucumán | 2:1 | ||||
| 23. Round | 05/10/2022 | Atlético Tucumán | - | Platense | 2:1 | ||||
| 25. Round | 14/10/2022 | Atlético Tucumán | - | Rosario Central | 1:1 | ||||
| 27. Round | 22/10/2022 | Defensa y Justicia | - | Atlético Tucumán | 3:1 | |
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