| 3. Round | 27/07/2021 | Lanús II | - | River Plate II | 0:1 | ||||
| 4. Round | 30/07/2021 | River Plate II | - | Huracán II | 2:0 | ||||
| 8. Round | 23/08/2021 | River Plate II | - | Aldosivi II | 3:0 | ||||
| 12. Round | 17/09/2021 | River Plate II | - | Arsenal de Sarandí II | 0:1 | ||||
| 16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 |  |
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| 20. Round | 05/11/2021 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 22. Round | 23/11/2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 |
Argentina