| 4. Round | 02/08/2021 | Atlético Tucumán II | - | Vélez Sarsfield II | 3:0 |  |
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| 5. Round | 06/08/2021 | Gimnasia de La Plata II | - | Atlético Tucumán II | 1:0 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán II | - | Independiente II | 0:0 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | |
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| 10. Round | 04/09/2021 | Atlético Tucumán II | - | Arsenal de Sarandí II | 0:1 | ||||
| 11. Round | 10/09/2021 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 | |
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| 12. Round | 18/09/2021 | Atlético Tucumán II | - | Boca Juniors II | 1:1 | |
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| 13. Round | 24/09/2021 | Banfield II | - | Atlético Tucumán II | 1:0 | ||||
| 15. Round | 08/10/2021 | Talleres de Córdoba II | - | Atlético Tucumán II | 1:1 | ||||
| 17. Round | 20/10/2021 | Estudiantes II | - | Atlético Tucumán II | 0:2 | |
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| 18. Round | 25/10/2021 | Atlético Tucumán II | - | Patronato de Paraná II | 0:1 | ||||
| 19. Round | 29/10/2021 | Platense II | - | Atlético Tucumán II | 0:1 | ||||
| 20. Round | 05/11/2021 | Atlético Tucumán II | - | Racing Club II | 2:1 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | |
Argentina