3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
4. Round | 22/08/2021 | Real España | - | Real Sociedad | 1:1 | ||||
8. Round | 12/09/2021 | Real España | - | Motagua | 2:1 | ||||
9. Round | 16/09/2021 | Honduras Progreso | - | Real España | 1:1 | ||||
10. Round | 20/09/2021 | Real España | - | Marathón | 0:1 | ||||
11. Round | 26/09/2021 | Real Sociedad | - | Real España | 0:4 | ||||
12. Round | 02/10/2021 | Real España | - | Olimpia | 1:1 | ||||
13. Round | 10/10/2021 | Victoria | - | Real España | 0:2 | ||||
14. Round | 17/10/2021 | Real España | - | Platense | 2:1 | ||||
1. Round | 21/10/2021 | Real España | - | Victoria | 1:1 | ||||
15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
18. Round | 10/11/2021 | Real España | - | Vida | 2:1 |