| 1. Round | 20/07/2019 | CF Pachuca | - | Club León | 1:3 |  |
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| 2. Round | 27/07/2019 | CD Veracruz | - | CF Pachuca | 3:3 | |
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| 3. Round | 04/08/2019 | CF Pachuca | - | Monarcas Morelia | 1:2 | ||||
| 4. Round | 10/08/2019 | Gallos Blancos | - | CF Pachuca | 2:1 | |
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| 5. Round | 17/08/2019 | Puebla FC | - | CF Pachuca | 0:4 | ||||
| 6. Round | 25/08/2019 | CF Pachuca | - | Atlas Guadalajara | 3:1 | ||||
| 7. Round | 28/08/2019 | CF América | - | CF Pachuca | 1:1 |  |
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| 9. Round | 16/09/2019 | Santos Laguna | - | CF Pachuca | 2:2 |  |
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| 10. Round | 22/09/2019 | CF Pachuca | - | Club Tijuana | 4:1 | |
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| 11. Round | 25/09/2019 | Deportivo Guadalajara | - | CF Pachuca | 2:4 | |
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| 12. Round | 28/09/2019 | CF Pachuca | - | Cruz Azul | 2:0 | |
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| 14. Round | 20/10/2019 | CF Pachuca | - | FC Juárez | 0:1 | |
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| 15. Round | 27/10/2019 | Deportivo Toluca | - | CF Pachuca | 2:0 | ||||
| 16. Round | 31/10/2019 | CF Pachuca | - | CF Monterrey | 2:3 | ||||
| 17. Round | 03/11/2019 | Club Necaxa | - | CF Pachuca | 1:2 | |
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| 18. Round | 10/11/2019 | UANL Tigres | - | CF Pachuca | 0:0 | |
Argentina