1. Round | 16/07/2021 | Arsenal de Sarandí II | - | San Lorenzo II | 0:1 | ||||
2. Round | 23/07/2021 | San Lorenzo II | - | Central Córdoba SdE II | 1:0 | ||||
4. Round | 30/07/2021 | San Lorenzo II | - | Banfield II | 2:3 | ||||
5. Round | 06/08/2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
14. Round | 01/10/2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 | ||||
15. Round | 11/10/2021 | San Lorenzo II | - | Colón de Santa Fe II | 1:1 | ||||
16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
17. Round | 18/10/2021 | San Lorenzo II | - | Lanús II | 0:0 | ||||
18. Round | 22/10/2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
3. Round | 11/11/2021 | Boca Juniors II | - | San Lorenzo II | 4:1 | ||||
21. Round | 18/11/2021 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 | ||||
22. Round | 23/11/2021 | Aldosivi II | - | San Lorenzo II | 1:0 | ||||
25. Round | 10/12/2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |