| 1. Round | 14/02/2021 | Defensa y Justicia | - | Huracán | 3:2 |  |
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| 2. Round | 20/02/2021 | Lanús | - | Defensa y Justicia | 2:1 | |
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| 3. Round | 26/02/2021 | Defensa y Justicia | - | Patronato de Paraná | 1:0 | |
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| 5. Round | 13/03/2021 | Defensa y Justicia | - | Newell's Old Boys | 4:0 | ||||
| 7. Round | 28/03/2021 | Defensa y Justicia | - | Vélez Sarsfield | 1:1 | ||||
| 11. Round | 25/04/2021 | Defensa y Justicia | - | Arsenal de Sarandí | 0:1 |
Argentina