| 1. Round | 06/03/2021 | UAI Urquiza | - | Atlético San Miguel | 1:0 | ||||
| 2. Round | 12/03/2021 | Atlético San Miguel | - | Talleres (RdE) | 1:1 | ||||
| 4. Round | 27/03/2021 | Deportivo Merlo | - | Atlético San Miguel | 1:0 |  |
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| 5. Round | 04/04/2021 | Atlético San Miguel | - | Flandria | 1:1 | |
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| 6. Round | 10/04/2021 | Cañuelas | - | Atlético San Miguel | 3:0 | ||||
| 7. Round | 17/04/2021 | Atlético San Miguel | - | Acassuso | 2:0 | ||||
| 8. Round | 25/04/2021 | Sacachispas | - | Atlético San Miguel | 1:0 | ||||
| 11. Round | 15/05/2021 | Atlético San Miguel | - | CA Los Andes | 1:0 | |
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| 12. Round | 07/06/2021 | Colegiales de Munro | - | Atlético San Miguel | 0:1 | |
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| 14. Round | 22/06/2021 | Defensores Unidos de Zárate | - | Atlético San Miguel | 2:0 | ||||
| 15. Round | 26/06/2021 | Atlético San Miguel | - | Villa San Carlos | 1:0 | ||||
| 16. Round | 03/07/2021 | Armenio | - | Atlético San Miguel | 1:1 | ||||
| 17. Round | 10/07/2021 | Atlético San Miguel | - | Comunicaciones de Buenos Aires | 2:0 |
Argentina