| 9. Round | 27/08/2021 | Arsenal de Sarandí II | - | Defensa y Justicia II | 0:1 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 | ||||
| 12. Round | 20/09/2021 | Defensa y Justicia II | - | Banfield II | 0:2 | ||||
| 13. Round | 24/09/2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 |  |
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| 15. Round | 07/10/2021 | Argentinos Juniors II | - | Defensa y Justicia II | 0:0 | ||||
| 16. Round | 13/10/2021 | Defensa y Justicia II | - | Estudiantes II | 1:2 | |
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| 17. Round | 18/10/2021 | Patronato de Paraná II | - | Defensa y Justicia II | 2:2 | ||||
| 19. Round | 28/10/2021 | Racing Club II | - | Defensa y Justicia II | 2:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 22. Round | 24/11/2021 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 | ||||
| 23. Round | 30/11/2021 | Defensa y Justicia II | - | Colón de Santa Fe II | 0:2 | ||||
| 24. Round | 03/12/2021 | River Plate II | - | Defensa y Justicia II | 2:1 | ||||
| 25. Round | 09/12/2021 | Defensa y Justicia II | - | Lanús II | 2:0 |
Argentina