| Group 1 | 28/04/2021 | Defensa y Justicia | - | Universitario de Deportes | 3:0 | ||||
| Group 1 | 05/05/2021 | Defensa y Justicia | - | Palmeiras | 1:2 |  |
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| Group 1 | 13/05/2021 | Universitario de Deportes | - | Defensa y Justicia | 1:1 | ||||
| Group 1 | 18/05/2021 | Palmeiras | - | Defensa y Justicia | 3:4 | ||||
| Round of 16 | 15/07/2021 | Defensa y Justicia | - | Flamengo RJ | 0:1 |
Argentina