| 28. Round | 02/10/2021 | Guillermo Brown | - | Tristan Suárez | 0:0 | ||||
| 29. Round | 09/10/2021 | Gimnasia de Jujuy | - | Guillermo Brown | 3:1 | ||||
| 30. Round | 17/10/2021 | Guillermo Brown | - | Instituto de Córdoba | 1:1 | ||||
| 31. Round | 23/10/2021 | Barracas Central | - | Guillermo Brown | 0:0 | ||||
| 32. Round | 31/10/2021 | Guillermo Brown | - | Independiente Rivadavia | 0:2 | ||||
| 33. Round | 06/11/2021 | Atlético Rafaela | - | Guillermo Brown | 0:1 | ||||
| 34. Round | 12/11/2021 | Guillermo Brown | - | All Boys | 1:0 |
Argentina