| 3. Round | 07/08/2022 | 1. FC Kaan-Marienborn | - | 1. FC Köln II | 1:1 | ||||
| 6. Round | 26/08/2022 | 1. FC Köln II | - | Fortuna Düsseldorf II | 3:1 | ||||
| 7. Round | 03/09/2022 | Preußen Münster | - | 1. FC Köln II | 4:2 | ||||
| 8. Round | 11/09/2022 | 1. FC Köln II | - | Wuppertaler SV | 2:1 | ||||
| 9. Round | 18/09/2022 | Rot Weiss Ahlen | - | 1. FC Köln II | 1:3 | ||||
| 10. Round | 01/10/2022 | 1. FC Köln II | - | SG Wattenscheid 09 | 3:2 | ||||
| 11. Round | 08/10/2022 | SC Wiedenbrück | - | 1. FC Köln II | 2:0 | ||||
| 12. Round | 15/10/2022 | 1. FC Köln II | - | 1. FC Bocholt | 1:3 | ||||
| 13. Round | 21/10/2022 | Alemannia Aachen | - | 1. FC Köln II | 3:1 |  |
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| 14. Round | 30/10/2022 | 1. FC Köln II | - | Bor. Mönchengladbach II | 0:2 | ||||
| 17. Round | 19/11/2022 | 1. FC Köln II | - | SV Lippstadt 08 | 0:0 | ||||
| 20. Round | 10/12/2022 | 1. FC Köln II | - | 1. FC Kaan-Marienborn | 0:1 |
USA