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| 02/09/2022 | 18:30 | Fortuna Köln | - | 1. FC Kaan-Marienborn | 3:0 (1:0) | |
| 03/09/2022 | 13:00 | Preußen Münster | - | 1. FC Köln II | 4:2 (2:1) | |
| 13:00 | Fortuna Düsseldorf II | - | SV Lippstadt 08 | 3:1 (1:0) | ||
| 13:00 | 1. FC Düren | - | SV Rödinghausen | 0:2 (0:0) | ||
| 13:00 | Rot-Weiß Oberhausen | - | FC Schalke 04 II | 1:3 (1:2) | ||
| 13:00 | SC Wiedenbrück | - | 1. FC Bocholt | 2:1 (1:0) | ||
| 13:00 | Rot Weiss Ahlen | - | Bor. Mönchengladbach II | 1:2 (1:1) | ||
| 13:00 | Wuppertaler SV | - | SV 19 Straelen | 2:1 (1:1) | ||
| 04/09/2022 | 13:00 | SG Wattenscheid 09 | - | Alemannia Aachen | 1:2 (0:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Preußen Münster | 7 | 5 | 1 | 1 | 19:8 | 11 | 16 |
| 2 |
|
1. FC Kaan-Marienborn | 7 | 5 | 1 | 1 | 12:8 | 4 | 16 |
| 3 |
|
SV Rödinghausen | 7 | 5 | 0 | 2 | 17:5 | 12 | 15 |
| 4 |
|
1. FC Düren | 7 | 4 | 1 | 2 | 10:10 | 0 | 13 |
| 5 |
|
Alemannia Aachen | 7 | 3 | 3 | 1 | 11:8 | 3 | 12 |
| 6 |
|
SV Lippstadt 08 | 7 | 4 | 0 | 3 | 12:11 | 1 | 12 |
| 7 |
|
SC Wiedenbrück | 7 | 3 | 2 | 2 | 11:6 | 5 | 11 |
| 8 |
|
Wuppertaler SV | 7 | 2 | 4 | 1 | 11:8 | 3 | 10 |
| 9 |
|
FC Schalke 04 II | 7 | 3 | 1 | 3 | 9:9 | 0 | 10 |
| 10 |
|
Fortuna Düsseldorf II | 7 | 3 | 1 | 3 | 10:11 | -1 | 10 |
| 11 |
|
Rot-Weiß Oberhausen | 7 | 3 | 1 | 3 | 13:18 | -5 | 10 |
| 12 |
|
Bor. Mönchengladbach II | 7 | 2 | 3 | 2 | 10:8 | 2 | 9 |
| 13 |
|
Rot Weiss Ahlen | 7 | 2 | 2 | 3 | 14:12 | 2 | 8 |
| 14 |
|
Fortuna Köln | 7 | 2 | 2 | 3 | 5:7 | -2 | 8 |
| 15 |
|
1. FC Köln II | 7 | 2 | 1 | 4 | 13:18 | -5 | 7 |
| 16 |
|
1. FC Bocholt | 7 | 1 | 2 | 4 | 10:18 | -8 | 5 |
| 17 |
|
SG Wattenscheid 09 | 7 | 1 | 1 | 5 | 8:21 | -13 | 4 |
| 18 |
|
SV 19 Straelen | 7 | 0 | 0 | 7 | 2:11 | -9 | 0 |
| Promotion | |
| Relegation | |
| Relegation |
