| 11. Round | 04/11/2000 | Denizlispor | - | İstanbulspor AŞ | 0:4 |  |
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| 19. Round | 04/02/2001 | İstanbulspor AŞ | - | Fenerbahçe | 1:2 | ||||
| 21. Round | 16/02/2001 | İstanbulspor AŞ | - | Gaziantepspor | 0:1 | ||||
| 22. Round | 25/02/2001 | Trabzonspor | - | İstanbulspor AŞ | 1:2 | ||||
| 24. Round | 10/03/2001 | Erzurumspor (1968-2015) | - | İstanbulspor AŞ | 1:3 | ||||
| 25. Round | 17/03/2001 | İstanbulspor AŞ | - | Bursaspor | 2:4 |  |
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| 27. Round | 08/04/2001 | İstanbulspor AŞ | - | Kocaelispor | 1:1 | ||||
| 28. Round | 14/04/2001 | İstanbulspor AŞ | - | Denizlispor | 1:3 | ||||
| 29. Round | 22/04/2001 | Gençlerbirliği | - | İstanbulspor AŞ | 3:0 | ||||
| 30. Round | 28/04/2001 | İstanbulspor AŞ | - | Siirt Jetpa Spor | 2:1 | ||||
| 32. Round | 12/05/2001 | İstanbulspor AŞ | - | Yozgatspor | 0:4 | ||||
| 33. Round | 19/05/2001 | Antalyaspor | - | İstanbulspor AŞ | 2:2 | ||||
| 34. Round | 25/05/2001 | İstanbulspor AŞ | - | Çaykur Rizespor | 1:0 |
Turkey