| 1. Round | 12/02/2021 | Rosario Central II | - | Argentinos Juniors II | 0:0 | ||||
| 2. Round | 19/02/2021 | River Plate II | - | Rosario Central II | 1:1 | ||||
| 3. Round | 26/02/2021 | Rosario Central II | - | Godoy Cruz II | 1:1 |  |
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| 4. Round | 05/03/2021 | Racing Club II | - | Rosario Central II | 2:1 | ||||
| 6. Round | 19/03/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:0 | ||||
| 8. Round | 02/04/2021 | San Lorenzo II | - | Rosario Central II | 0:0 | ||||
| 9. Round | 09/04/2021 | Rosario Central II | - | Banfield II | 1:1 | ||||
| 10. Round | 16/04/2021 | Aldosivi II | - | Rosario Central II | 1:3 | ||||
| 12. Round | 30/04/2021 | Rosario Central II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Round | 07/05/2021 | Platense II | - | Rosario Central II | 1:0 |
Argentina