| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 9. Round | 30/08/2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 11. Round | 14/09/2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 15. Round | 08/10/2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 |
Argentina