| 1. Round | 06/02/2022 | Albion | - | Rentistas | 3:5 | ||||
| 3. Round | 19/02/2022 | Albion | - | Peñarol | 1:1 | ||||
| 4. Round | 28/02/2022 | Montevideo City Torque | - | Albion | 1:2 | ||||
| 9. Round | 16/04/2022 | Albion | - | Cerro Largo | 2:1 |  |
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| 10. Round | 24/04/2022 | Fénix | - | Albion | 2:1 | |
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| 11. Round | 07/05/2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 12. Round | 15/05/2022 | Albion | - | Cerrito | 2:2 | ||||
| 13. Round | 21/05/2022 | Nacional | - | Albion | 2:0 |
Uruguay