| 1. Round | 06/03/2021 | Villa San Carlos | - | Cañuelas | 1:1 |  |
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| 2. Round | 13/03/2021 | Acassuso | - | Villa San Carlos | 2:1 | ||||
| 4. Round | 29/03/2021 | Justo José de Urquiza | - | Villa San Carlos | 2:1 | ||||
| 7. Round | 17/04/2021 | Villa San Carlos | - | Colegiales de Munro | 3:2 | ||||
| 11. Round | 16/05/2021 | Armenio | - | Villa San Carlos | 1:1 | ||||
| 15. Round | 26/06/2021 | Atlético San Miguel | - | Villa San Carlos | 1:0 | ||||
| 16. Round | 02/07/2021 | Villa San Carlos | - | Deportivo Merlo | 0:0 | ||||
| 17. Round | 09/07/2021 | Flandria | - | Villa San Carlos | 1:0 |
Argentina