1. Round | 06/02/2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
2. Round | 13/02/2022 | Guaraní | - | Sol de América | 0:1 | ||||
3. Round | 19/02/2022 | Cerro Porteño | - | Guaraní | 2:0 | ||||
6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
8. Round | 04/04/2022 | Guaraní | - | Tacuary | 1:2 | ||||
13. Round | 01/05/2022 | Sol de América | - | Guaraní | 2:2 | ||||
14. Round | 09/05/2022 | Guaraní | - | Cerro Porteño | 1:2 |