| 1. Round | 16/07/2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 4. Round | 30/07/2021 | Colón de Santa Fe II | - | Godoy Cruz II | 0:0 | ||||
| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 16. Round | 15/10/2021 | Godoy Cruz II | - | Central Córdoba SdE II | 3:0 | ||||
| 17. Round | 19/10/2021 | Boca Juniors II | - | Godoy Cruz II | 6:0 | ||||
| 18. Round | 24/10/2021 | Godoy Cruz II | - | Banfield II | 2:0 | ||||
| 19. Round | 31/10/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Round | 05/11/2021 | Godoy Cruz II | - | Talleres de Córdoba II | 1:1 | ||||
| 24. Round | 03/12/2021 | Godoy Cruz II | - | Platense II | 0:2 | ||||
| 25. Round | 11/12/2021 | Racing Club II | - | Godoy Cruz II | 2:1 |
Argentina