| 5. Round | 17/10/2020 | Willem II | - | FC Twente | 0:3 | ||||
| 6. Round | 24/10/2020 | FC Utrecht | - | FC Twente | 2:1 | ||||
| 7. Round | 31/10/2020 | FC Twente | - | PEC Zwolle | 5:1 | ||||
| 8. Round | 07/11/2020 | ADO Den Haag | - | FC Twente | 2:4 | ||||
| 9. Round | 22/11/2020 | FC Twente | - | PSV Eindhoven | 1:1 | ||||
| 10. Round | 27/11/2020 | FC Twente | - | RKC Waalwijk | 0:2 | ||||
| 12. Round | 13/12/2020 | FC Twente | - | AZ Alkmaar | 1:3 | ||||
| 13. Round | 19/12/2020 | VVV-Venlo | - | FC Twente | 1:2 | ||||
| 14. Round | 22/12/2020 | FC Twente | - | Sparta Rotterdam | 0:2 |
Netherlands