| 1. Round | 25/07/2021 | Pumas UNAM [U18] | - | Atlas Guadalajara [U18] | 1:2 | ||||
| 2. Round | 31/07/2021 | CF Monterrey [U18] | - | Pumas UNAM [U18] | 1:2 | ||||
| 3. Round | 08/08/2021 | Pumas UNAM [U18] | - | Atlético San Luis [U18] | 1:1 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 10. Round | 25/09/2021 | UANL Tigres [U18] | - | Pumas UNAM [U18] | 6:0 | ||||
| 12. Round | 03/10/2021 | CF América [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 13. Round | 17/10/2021 | Pumas UNAM [U18] | - | FC Juárez [U18] | 2:0 | ||||
| 14. Round | 20/10/2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 15. Round | 24/10/2021 | Pumas UNAM [U18] | - | Club Tijuana [U18] | 2:2 | ||||
| 16. Round | 30/10/2021 | CF Pachuca [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 11. Round | 04/11/2021 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 2:2 |
Mexico