| 16. Round | 10/01/2022 | Sunderland AFC U23 | - | Reading FC U23 | 2:0 | ||||
| 18. Round | 24/01/2022 | Sunderland AFC U23 | - | Wolverhampton Wanderers U23 | 1:2 | ||||
| 19. Round | 04/02/2022 | Fulham FC U23 | - | Sunderland AFC U23 | 2:0 | ||||
| 20. Round | 21/02/2022 | Sunderland AFC U23 | - | West Bromwich Albion U23 | 0:1 | ||||
| 22. Round | 14/03/2022 | Nottingham Forest U23 | - | Sunderland AFC U23 | 3:0 |  |
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| 15. Round | 18/04/2022 | Sunderland AFC U23 | - | Aston Villa U23 | 1:3 | |
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| 26. Round | 01/05/2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |
England