| 1. Round | 18/01/2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Round | 21/01/2021 | Montevideo Wanderers | - | Danubio | 2:0 |  |
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| 3. Round | 31/01/2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Round | 04/02/2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Round | 06/02/2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:1 |  |
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| 6. Round | 10/02/2021 | Montevideo Wanderers | - | Rentistas | 3:2 | |
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| 7. Round | 13/02/2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 | |
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| 8. Round | 17/02/2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 9. Round | 21/02/2021 | Montevideo Wanderers | - | Peñarol | 0:1 | |
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| 10. Round | 27/02/2021 | River Plate | - | Montevideo Wanderers | 1:1 | |
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| 13. Round | 21/03/2021 | Montevideo Wanderers | - | Progreso | 3:0 dec. | ||||
| 14. Round | 25/03/2021 | Fénix | - | Montevideo Wanderers | 3:3 |
Argentina