| 1. Round | 07/02/2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
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| 2. Round | 14/02/2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 |  |
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| 3. Round | 20/02/2022 | Fénix | - | Montevideo Wanderers | 0:3 | |
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| 4. Round | 26/02/2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | |
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| 5. Round | 13/03/2022 | Albion | - | Montevideo Wanderers | 1:1 | ||||
| 6. Round | 20/03/2022 | Montevideo Wanderers | - | Nacional | 2:2 | |
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| 7. Round | 02/04/2022 | Danubio | - | Montevideo Wanderers | 0:0 | ||||
| 8. Round | 11/04/2022 | Montevideo Wanderers | - | Deportivo Maldonado | 0:1 | ||||
| 9. Round | 18/04/2022 | Rentistas | - | Montevideo Wanderers | 1:3 | ||||
| 10. Round | 23/04/2022 | Montevideo Wanderers | - | Liverpool | 0:0 | ||||
| 11. Round | 08/05/2022 | Peñarol | - | Montevideo Wanderers | 1:0 | ||||
| 12. Round | 15/05/2022 | Montevideo Wanderers | - | Montevideo City Torque | 1:1 | ||||
| 13. Round | 22/05/2022 | Cerrito | - | Montevideo Wanderers | 0:2 | ||||
| 15. Round | 06/06/2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Argentina