| 1. Round | 10/01/2021 | Deportivo Toluca | - | Gallos Blancos | 3:1 | ||||
| 2. Round | 18/01/2021 | Gallos Blancos | - | Atlas Guadalajara | 1:0 | ||||
| 3. Round | 25/01/2021 | Gallos Blancos | - | Pumas UNAM | 2:0 |  |
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| 5. Round | 05/02/2021 | Gallos Blancos | - | CF Pachuca | 3:1 | ||||
| 6. Round | 14/02/2021 | CF América | - | Gallos Blancos | 2:1 | ||||
| 7. Round | 21/02/2021 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
| 9. Round | 04/03/2021 | Gallos Blancos | - | Deportivo Guadalajara | 2:2 |  |
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| 10. Round | 07/03/2021 | CF Monterrey | - | Gallos Blancos | 2:1 | ||||
| 11. Round | 15/03/2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | |
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| 12. Round | 21/03/2021 | Club Tijuana | - | Gallos Blancos | 3:1 | ||||
| 13. Round | 05/04/2021 | Gallos Blancos | - | UANL Tigres | 0:1 | ||||
| 14. Round | 12/04/2021 | Gallos Blancos | - | Santos Laguna | 1:0 | ||||
| 15. Round | 17/04/2021 | Club Necaxa | - | Gallos Blancos | 0:0 | ||||
| 16. Round | 26/04/2021 | Gallos Blancos | - | FC Juárez | 1:0 | |
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| 17. Round | 01/05/2021 | Club León | - | Gallos Blancos | 2:1 | |
Uruguay