| Group 1 | 10/03/2016 | River Plate | - | São Paulo FC | 1:1 |  |
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| Group 1 | 16/03/2016 | The Strongest | - | River Plate | 1:1 | ||||
| Group 1 | 06/04/2016 | River Plate | - | The Strongest | 6:0 |  |
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| Group 1 | 14/04/2016 | São Paulo FC | - | River Plate | 2:1 | ||||
| Group 1 | 22/04/2016 | River Plate | - | Trujillanos FC | 4:3 | ||||
| Round of 16 | 04/05/2016 | River Plate | - | Independiente del Valle | 1:0 | |
Argentina