| 2. Round | 23/07/2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 11. Round | 10/09/2021 | Gimnasia de La Plata II | - | Vélez Sarsfield II | 2:3 | ||||
| 13. Round | 24/09/2021 | Sarmiento de Junín II | - | Vélez Sarsfield II | 0:4 | ||||
| 14. Round | 01/10/2021 | Vélez Sarsfield II | - | Independiente II | 0:0 | ||||
| 15. Round | 08/10/2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 16. Round | 13/10/2021 | Vélez Sarsfield II | - | Arsenal de Sarandí II | 1:1 | ||||
| 23. Round | 29/11/2021 | Estudiantes II | - | Vélez Sarsfield II | 2:3 |
Argentina