| 22. Round | 02/08/2022 | Deportes Copiapó | - | Deportes Melipilla | 2:1 |  |
|||
| 25. Round | 25/08/2022 | Cobreloa | - | Deportes Melipilla | 1:0 | ||||
| 26. Round | 31/08/2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 27. Round | 06/09/2022 | Santiago Wanderers | - | Deportes Melipilla | 2:2 | ||||
| 28. Round | 13/09/2022 | Deportes Melipilla | - | Deportes Temuco | 0:1 | ||||
| 29. Round | 24/09/2022 | Barnechea | - | Deportes Melipilla | 4:2 | ||||
| 34. Round | 01/11/2022 | Deportes Melipilla | - | Deportes Iquique | 0:0 |
Argentina