| 1. Round | 16/07/2021 | Independiente II | - | Argentinos Juniors II | 3:0 | ||||
| 2. Round | 23/07/2021 | Estudiantes II | - | Independiente II | 2:2 | ||||
| 3. Round | 27/07/2021 | Independiente II | - | Patronato de Paraná II | 0:1 | ||||
| 4. Round | 30/07/2021 | Platense II | - | Independiente II | 1:0 | ||||
| 5. Round | 06/08/2021 | Independiente II | - | Racing Club II | 1:1 | ||||
| 6. Round | 13/08/2021 | Rosario Central II | - | Independiente II | 3:1 | ||||
| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 12. Round | 17/09/2021 | Huracán II | - | Independiente II | 2:0 | ||||
| 16. Round | 14/10/2021 | Aldosivi II | - | Independiente II | 0:1 | ||||
| 17. Round | 18/10/2021 | Independiente II | - | Sarmiento de Junín II | 2:1 | ||||
| 18. Round | 22/10/2021 | Independiente II | - | Unión de Santa Fe II | 2:0 | ||||
| 19. Round | 29/10/2021 | Newell's Old Boys II | - | Independiente II | 1:0 |
Argentina