| 1. Round | 24/07/2021 | CF Monterrey [U18] | - | Puebla FC [U18] | 0:0 | ||||
| 3. Round | 07/08/2021 | CF América [U18] | - | Puebla FC [U18] | 1:0 | ||||
| 8. Round | 10/09/2021 | Puebla FC [U18] | - | Atlético San Luis [U18] | 1:3 | ||||
| 12. Round | 01/10/2021 | Puebla FC [U18] | - | CF Pachuca [U18] | 0:2 | ||||
| 14. Round | 19/10/2021 | Puebla FC [U18] | - | Mazatlán FC [U18] | 0:2 |
Mexico