| 12. Round | 17/09/2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 18. Round | 24/10/2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 21. Round | 20/11/2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 |  |
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| 22. Round | 24/11/2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | Lanús II | - | Rosario Central II | 2:3 | |
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| 25. Round | 10/12/2021 | Rosario Central II | - | Huracán II | 2:0 |
Argentina