| 1. Round | 25/06/2022 | Atlas Guadalajara [] | - | Club León [] | 2:0 | ||||
| 2. Round | 02/07/2022 | Club León [] | - | UANL Tigres [] | 3:0 | ||||
| 4. Round | 16/07/2022 | Deportivo Guadalajara [] | - | Club León [] | 2:1 | ||||
| 6. Round | 30/07/2022 | CF Monterrey [] | - | Club León [] | 2:2 | ||||
| 7. Round | 05/08/2022 | Club León [] | - | Atlético San Luis [] | 2:0 | ||||
| 8. Round | 13/08/2022 | Mazatlán FC [] | - | Club León [] | 3:0 | ||||
| 11. Round | 03/09/2022 | Santos Laguna [] | - | Club León [] | 2:0 |
Mexico