| 2. Round | 23/05/2021 | Plaza Colonia | - | Montevideo City Torque | 1:0 | ||||
| 3. Round | 29/05/2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 4. Round | 05/06/2021 | Plaza Colonia | - | Nacional | 1:2 | ||||
| 8. Round | 28/06/2021 | Plaza Colonia | - | Cerro Largo | 1:1 |  |
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| 9. Round | 05/07/2021 | Progreso | - | Plaza Colonia | 1:2 | ||||
| 11. Round | 17/07/2021 | Deportivo Maldonado | - | Plaza Colonia | 0:1 | ||||
| 12. Round | 01/08/2021 | Fénix | - | Plaza Colonia | 0:1 | ||||
| 13. Round | 09/08/2021 | Plaza Colonia | - | Boston River | 0:0 | ||||
| 14. Round | 16/08/2021 | Montevideo Wanderers | - | Plaza Colonia | 0:2 | |
Argentina