| 2. Round | 25/08/2021 | Družstevník Radimov | - | FK Senica | 2:4 pso | ||||
| 3. Round | 22/09/2021 | TJ Nafta Gbely | - | FK Senica | 0:3 |  |
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| 4. Round | 02/11/2021 | OŠK Bešeňová | - | FK Senica | 1:5 | ||||
| Round of 16 | 01/03/2022 | ŠK 2020 Šašová | - | FK Senica | 0:3 | ||||
| Semi-finals | 06/04/2022 | Spartak Trnava | - | FK Senica | 3:0 | ||||
| Semi-finals | 20/04/2022 | FK Senica | - | Spartak Trnava | 0:4 |
Greece