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| 19/10/2021 | 13:00 | 1. MFK Kežmarok | - | MFK Skalica | 0:3 | |
| 20/10/2021 | 14:00 | OFK Baník Lehota | - | FK Pohronie | 0:1 (0:1) | |
| 26/10/2021 | 16:00 | FK Železiarne Podbrezová | - | Spartak Trnava | 6:7 (0:2, 2:2) pso | |
| 27/10/2021 | 13:30 | FC Slovan Galanta | - | FK Humenné | 1:2 | |
| 13:30 | TJD Príbelce | - | AS Trenčín | 0:3 (0:0) | ||
| 13:30 | ŠK Belá | - | MFK Vranov nad Topľou | 0:1 | ||
| 13:30 | Slávia TU Košice | - | Slovan Bratislava | 0:5 (0:1) | ||
| 13:30 | ŠK 2020 Šašová | - | TJ Rovinka | 3:2 (3:1) | ||
| 15:00 | MFK Ružomberok | - | SK Odeva Lipany | 1:0 (0:0) | ||
| 02/11/2021 | 12:30 | OŠK Bešeňová | - | FK Senica | 1:5 (0:1) | |
| 12:30 | MFK Dolný Kubín | - | MŠK Žilina | 2:3 (2:2) | ||
| 03/11/2021 | 12:00 | Slavoj Spišská Belá | - | ŠTK 1914 Šamorín | 0:12 | |
| 10/11/2021 | 12:30 | KFC Komárno | - | MFK Zemplín Michalovce | 2:1 (0:0) | |
| 21/11/2021 | 12:00 | FC Rohožník | - | FC Košice | 0:2 | |
| 12/02/2022 | 15:00 | MŠK Tesla Stropkov | - | MŠK Púchov | 1:2 | |
| 15/02/2022 | 13:00 | MŠK Spišské Podhradie | - | Zlaté Moravce | 0:7 (0:3) |
