| 2. Round | 16/01/2022 | Deportivo Toluca [U18] | - | Santos Laguna [U18] | 2:2 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U18] | - | Deportivo Toluca [U18] | 0:1 | ||||
| 10. Round | 13/03/2022 | Deportivo Toluca [U18] | - | CF Pachuca [U18] | 0:2 | ||||
| 11. Round | 20/03/2022 | CF América [U18] | - | Deportivo Toluca [U18] | 3:2 | ||||
| 12. Round | 03/04/2022 | Deportivo Toluca [U18] | - | Puebla FC [U18] | 0:1 | ||||
| 13. Round | 09/04/2022 | Deportivo Toluca [U18] | - | Deportivo Guadalajara [U18] | 3:3 |  |
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| 15. Round | 19/04/2022 | Deportivo Toluca [U18] | - | FC Juárez [U18] | 4:0 | ||||
| 16. Round | 24/04/2022 | Deportivo Toluca [U18] | - | Atlas Guadalajara [U18] | 1:0 | ||||
| 14. Round | 27/04/2022 | UANL Tigres [U18] | - | Deportivo Toluca [U18] | 1:1 | ||||
| 17. Round | 01/05/2022 | Club León [U18] | - | Deportivo Toluca [U18] | 0:0 |  |
Mexico