| 3. Round | 21/01/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 6. Round | 20/02/2022 | Deportivo Toluca [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U20] | - | Club Tijuana [U20] | 3:1 | ||||
| 9. Round | 04/03/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 1:2 |
Mexico