| 1. Round | 16/07/2021 | Unión de Santa Fe II | - | Boca Juniors II | 1:0 | ||||
| 2. Round | 23/07/2021 | Banfield II | - | Boca Juniors II | 1:3 |  |
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| 4. Round | 02/08/2021 | Talleres de Córdoba II | - | Boca Juniors II | 1:1 | |
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| 5. Round | 06/08/2021 | Boca Juniors II | - | Argentinos Juniors II | 0:1 | ||||
| 6. Round | 13/08/2021 | Estudiantes II | - | Boca Juniors II | 2:1 | ||||
| 7. Round | 19/08/2021 | Boca Juniors II | - | Patronato de Paraná II | 4:0 | ||||
| 8. Round | 24/08/2021 | Platense II | - | Boca Juniors II | 2:2 | ||||
| 9. Round | 27/08/2021 | Boca Juniors II | - | Racing Club II | 4:0 | ||||
| 10. Round | 03/09/2021 | Rosario Central II | - | Boca Juniors II | 1:3 | |
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| 3. Round | 11/11/2021 | Boca Juniors II | - | San Lorenzo II | 4:1 | ||||
| 23. Round | 30/11/2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 25. Round | 11/12/2021 | Boca Juniors II | - | Central Córdoba SdE II | 7:0 |
Argentina