| 3. Round | 09/08/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 4. Round | 15/08/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 0:2 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 7. Round | 28/08/2021 | UANL Tigres [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U20] | - | Atlas Guadalajara [U20] | 1:2 |  |
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| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | |
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| 11. Round | 28/09/2021 | Atlas Guadalajara [U20] | - | Puebla FC [U20] | 3:3 | |
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| 12. Round | 02/10/2021 | Deportivo Guadalajara [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 14. Round | 19/10/2021 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 15. Round | 24/10/2021 | Atlético San Luis [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 17. Round | 04/11/2021 | Atlas Guadalajara [U20] | - | Gallos Blancos [U20] | 1:1 | |
Mexico