| 1. Round | 05/11/2021 | Edinburgh City FC | - | Albion Rovers | 0:4 | ||||
| 15. Round | 03/12/2021 | Edinburgh City FC | - | Annan Athletic | 0:1 | ||||
| 16. Round | 11/12/2021 | Stenhousemuir FC | - | Edinburgh City FC | 2:2 | ||||
| 17. Round | 17/12/2021 | Edinburgh City FC | - | Forfar Athletic | 0:4 | ||||
| 18. Round | 22/12/2021 | Cowdenbeath FC | - | Edinburgh City FC | 1:2 | ||||
| 20. Round | 07/01/2022 | Edinburgh City FC | - | Elgin City | 2:2 | ||||
| 24. Round | 05/02/2022 | Stranraer FC | - | Edinburgh City FC | 0:2 | ||||
| 26. Round | 19/02/2022 | Annan Athletic | - | Edinburgh City FC | 2:1 | ||||
| 27. Round | 25/02/2022 | Edinburgh City FC | - | Cowdenbeath FC | 1:0 | ||||
| 22. Round | 02/03/2022 | Edinburgh City FC | - | Stenhousemuir FC | 1:1 | ||||
| 28. Round | 05/03/2022 | Albion Rovers | - | Edinburgh City FC | 0:1 | ||||
| 29. Round | 12/03/2022 | Stenhousemuir FC | - | Edinburgh City FC | 0:0 |  |
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| 31. Round | 26/03/2022 | Elgin City | - | Edinburgh City FC | 2:0 |
Scotland